Il17a (26-158, His-Tag) Mouse Recombinant Protein
CAT＃: TP721376
Recombinant mouse IL-17A protein
View other "IL17" proteins (8)
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CNY 1688.00
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CNY 2700.00
CNY 3790.00
Specifications
| Product Data | |
| Species | Mouse |
| Expression Host | Baculovirus |
| Expression cDNA Clone or AA Sequence |
AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
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| Tag | His-Tag |
| Predicted MW | 16kDa (141aa) |
| Concentration | 0.5mg/ml (determined by absorbance at 280nm) |
| Purity | > 95% by SDS-PAGE |
| Buffer | Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol |
| Applications | SDS-PAGE, Bioactivity |
| Storage | Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Bioactivity | The activity is determined by the IL-6 ELISA in a using NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 2 ng/ml. |
| Endotoxin | < 1 EU per 1ug of protein (determined by LAL method) |
| Reference Data | |
| RefSeq | NP_034682.1 |
| Locus ID | 3605 |
| UniProt ID | Q62386 |
| Synonyms | Interleukin-17A, IL17A, IL-17, IL-17A, Il17, Cytotoxic T-lymphocyte-associated antigen 8. Ctla-8, Ctla8 |
| Summary | IL-17A, also known as CTLA‑8, is a cytokine that belongs to the Interleukin‑17 family. It produced by activated T cells and plays an important role in anti‑microbial and chronic inflammation. Mouse IL‑17A shares 61% amino acid sequence identity with human IL‑17A. It promotes protective mucosal and epidermal inflammation in response to microbial infection and induces chemokine production, neutrophil influx, and the production of antibacterial peptides. It can stimulate the expression of IL-6 and PTGS2/COX-2, as well as enhance the production of nitric oxide(NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Also, IL‑17A has been shown to exert either tumorigenic or anti‑tumor effects. Recombinant mouse IL-17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
| Protein Families | Druggable Genome, Secreted Protein |
| Protein Pathways | Cytokine-cytokine receptor interaction |
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