Il17a (26-158, His-Tag) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	Baculovirus
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA
Tag	His-Tag
Predicted MW	16kDa (141aa)
Concentration	0.5mg/ml (determined by absorbance at 280nm)
Purity	> 95% by SDS-PAGE
Buffer	Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Applications	SDS-PAGE, Bioactivity
Storage	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Bioactivity	The activity is determined by the IL-6 ELISA in a using NIH/3T3 mouse embryonic fibroblast cells. The ED50 range ≤ 2 ng/ml.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Reference Data
RefSeq	NP_034682.1
Locus ID	3605
UniProt ID	Q62386
Synonyms	Interleukin-17A, IL17A, IL-17, IL-17A, Il17, Cytotoxic T-lymphocyte-associated antigen 8. Ctla-8, Ctla8
Summary	IL-17A, also known as CTLA‑8, is a cytokine that belongs to the Interleukin‑17 family. It produced by activated T cells and plays an important role in anti‑microbial and chronic inflammation. Mouse IL‑17A shares 61% amino acid sequence identity with human IL‑17A. It promotes protective mucosal and epidermal inflammation in response to microbial infection and induces chemokine production, neutrophil influx, and the production of antibacterial peptides. It can stimulate the expression of IL-6 and PTGS2/COX-2, as well as enhance the production of nitric oxide(NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis. Also, IL‑17A has been shown to exert either tumorigenic or anti‑tumor effects. Recombinant mouse IL-17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction

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