VKORC1 (NM_206824) Human Mass Spec Standard

Specifications

Product Data
Description	VKORC1 MS Standard C13 and N15-labeled recombinant protein (NP_996560)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC214831
Predicted MW	9.7 kDa
Protein Sequence	Sequence Link (showhide) >RC214831 representing NM_206824 Red=Cloning site Green=Tags(s) MGSTWGSPGWVRLALCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRLPADTLGLCPDA AELPGVSRWFCLPGLDPVLRAL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_996560
RefSeq Size	907
RefSeq ORF	276
Synonyms	EDTP308; MST134; MST576; VKCFD2; VKOR
Locus ID	79001
Cytogenetics	16p11.2
Summary	This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Protein Families	Transmembrane

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