VKORC1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1.
Isotype	IgG
Formulation	VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	VKORC1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	vitamin K epoxide reductase complex subunit 1
Database Link	NP_076869 Entrez Gene 27973 MouseEntrez Gene 79001 Human UniProt ID Q9BQB6
Background	VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
Synonyms	EDTP308; MST134; MST576; VKCFD2; VKOR
Reference Data
Protein Families	Transmembrane

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