Human KIAA0748 (TESPA1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TESPA1
Locus ID	9840
Kit Components	GA106633G1, KIAA0748 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106633G2, KIAA0748 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106633G3, KIAA0748 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001098815, NM_001136030, NM_001261844, NM_014796, NM_001351148, NM_001351149, NM_001351150, NM_001351151, NM_001351152, NM_001351153, NM_001351154, NM_001351155, NR_147062, NR_147063, NR_147064, NR_147065, NR_147066, NR_147067, NR_147068, NR_147069, NR_147070, NR_147071, NR_147072, NR_147073
Synonyms	HSPC257; KIAA0748
Summary	Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment.[UniProtKB/Swiss-Prot Function]

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