KIAA0748 (TESPA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	TESPA1 antibody was raised against an 18 amino acid peptide near the amino terminus of human TESPA1.
Isotype	IgG
Formulation	TESPA1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	TESPA1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 57 kDa; Observed: 60 kDa
Gene Name	thymocyte expressed, positive selection associated 1
Database Link	NP_001129502 Entrez Gene 9840 Human UniProt ID A2RU30
Background	TESPA1 is a critical component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development (1). TESPA1 encodes a protein of 458 amino acids and is highly conserved among vertebrate species (2). TESPA1 expression was tightly regulated during T cell development, with highest expression at the DP stage (3). TESPA1 deficiency resulted in failure of positive selection and substantially fewer of CD4+ and CD8+ SP cells in the thymus (1,4).
Synonyms	HSPC257; KIAA0748
Reference Data

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