DDX58 Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence from TrueORF clone, RC217615, encoding the full-length of DDX58
Tag	C-DDK-His
Predicted MW	106.4 kDa
Concentration	>0.05 ug/ul as determined by microplate Bradford method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	100 mM KCl, 6 mM MgCl2, 1 mM DTT, 10mM HEPES pH7.0 (+ 330 ug/ml Flag peptide),50% glycerine
Note	For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_055129.2
Locus ID	23586
UniProt ID	O95786
Refseq Size	4372
Cytogenetics	9p21.1
Refseq ORF	2775
Synonyms	RIG-I; RIG1; RIGI; RLR-1; SGMRT2
Summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2. [provided by RefSeq, Aug 2020]
Protein Pathways	Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

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