ASIP (NM_001672) Human Mass Spec Standard

Specifications

Product Data
Description	ASIP MS Standard C13 and N15-labeled recombinant protein (NP_001663)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC222654
Predicted MW	14.52 kDa
Protein Sequence	Sequence Link (showhide) >RC222654 representing NM_001672 Red=Cloning site Green=Tags(s) MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKK RSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001663
RefSeq Size	584
RefSeq ORF	396
Synonyms	AGSW; AGTI; AGTIL; ASP; SHEP9
Locus ID	434
Cytogenetics	20q11.22
Summary	In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]
Protein Families	Secreted Protein
Protein Pathways	Melanogenesis

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