AGRP (NM_001138) Human Mass Spec Standard

Specifications

Product Data
Description	AGRP MS Standard C13 and N15-labeled recombinant protein (NP_001129)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC217144
Predicted MW	14.4 kDa
Protein Sequence	Sequence Link (showhide) >RC217144 protein sequence Red=Cloning site Green=Tags(s) MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQAL AEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001129
RefSeq Size	783
RefSeq ORF	396
Synonyms	AGRT; ART; ASIP2
Locus ID	181
Cytogenetics	16q22.1
Summary	This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Adipocytokine signaling pathway

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