IP10 (CXCL10) (NM_001565) Human Mass Spec Standard

Specifications

Product Data
Description	CXCL10 MS Standard C13 and N15-labeled recombinant protein (NP_001556)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC203141
Predicted MW	10.9 kDa
Protein Sequence	Sequence Link (showhide) >RC203141 protein sequence Red=Cloning site Green=Tags(s) MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKG EKRCLNPESKAIKNLLKAVSKERSKRSP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001556
RefSeq Size	1227
RefSeq ORF	294
Synonyms	C7; crg-2; gIP-10; IFI10; INP10; IP-10; mob-1; SCYB10
Locus ID	3627
Cytogenetics	4q21.1
Summary	This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020]
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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