PRPS1 (NM_002764) Human Mass Spec Standard

Specifications

Product Data
Description	PRPS1 MS Standard C13 and N15-labeled recombinant protein (NP_002755)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200698
Predicted MW	34.8 kDa
Protein Sequence	Sequence Link (showhide) >RC200698 protein sequence Red=Cloning site Green=Tags(s) MPNIKIFSGSSHQDLSQKIADRLGLELGKVVTKKFSNQETCVEIGESVRGEDVYIVQSGCGEINDNLMEL LIMINACKIASASRVTAVIPCFPYARQDKKDKSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI PVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERKKANEVDRMVLVGD VKDRVAILVDDMADTCGTICHAADKLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDK MKHCSKIQVIDISMILAEAIRRTHNGESVSYLFSHVPL TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_002755
RefSeq Size	2156
RefSeq ORF	954
Synonyms	ARTS; CMTX5; DFN2; DFNX1; PPRibP; PRS-I; PRSI
Locus ID	5631
Cytogenetics	Xq22.3
Summary	This gene encodes an enzyme that catalyzes the phosphoribosylation of ribose 5-phosphate to 5-phosphoribosyl-1-pyrophosphate, which is necessary for purine metabolism and nucleotide biosynthesis. Defects in this gene are a cause of phosphoribosylpyrophosphate synthetase superactivity, Charcot-Marie-Tooth disease X-linked recessive type 5 and Arts Syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, Pentose phosphate pathway, Purine metabolism

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