GSK3 beta (GSK3B) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	GSK3 beta
Locus ID	2932
Kit Components	KN200468G1, GSK3 beta gRNA vector 1 in pCas-Guide CRISPR vector KN200468G2, GSK3 beta gRNA vector 2 in pCas-Guide CRISPR vector KN200468BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_001146156, NM_002093, NM_001354596
Synonyms	glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta; GSK3beta isoform
Summary	The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]

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