Human TOP1MT activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TOP1MT
Locus ID	116447
Kit Components	GA114595G1, TOP1MT gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114595G2, TOP1MT gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114595G3, TOP1MT gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001258446, NM_001258447, NM_052963
Summary	This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

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