Human TMEM107 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TMEM107
Locus ID	84314
Kit Components	GA113508G1, TMEM107 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA113508G2, TMEM107 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA113508G3, TMEM107 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_032354, NM_183065, NM_001351278, NM_001351279, NM_001351280, NR_147092
Synonyms	GRVS638; PRO1268
Summary	This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017]

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