Human PLEKHG2 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PLEKHG2
Locus ID	64857
Kit Components	GA112180G1, PLEKHG2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112180G2, PLEKHG2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112180G3, PLEKHG2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_022835, NM_001351693, NM_001351694
Synonyms	ARHGEF42; CLG; LDAMD
Summary	The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017]

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