Human CWC22 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CWC22
Locus ID	57703
Kit Components	GA111697G1, CWC22 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111697G2, CWC22 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111697G3, CWC22 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_020943
Synonyms	EIF4GL; fSAPb; NCM
Summary	Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay.[UniProtKB/Swiss-Prot Function]

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