Human TMEM66 (SARAF) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SARAF
Locus ID	51669
Kit Components	GA109936G1, TMEM66 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109936G2, TMEM66 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109936G3, TMEM66 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001284239, NM_016127
Synonyms	FOAP-7; HSPC035; TMEM66; XTP3
Summary	Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.[UniProtKB/Swiss-Prot Function]

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