Human LRRC8B activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	LRRC8B
Locus ID	23507
Kit Components	GA108351G1, LRRC8B gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108351G2, LRRC8B gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108351G3, LRRC8B gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001134476, NM_015350, NM_001369817, NM_001369819
Synonyms	TA-LRRP; TALRRP
Summary	Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731).[UniProtKB/Swiss-Prot Function]

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