Human SPFH2 (ERLIN2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ERLIN2
Locus ID	11160
Kit Components	GA107682G1, SPFH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA107682G2, SPFH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA107682G3, SPFH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001003790, NM_001003791, NM_007175, NM_001362878, NM_001362880
Synonyms	C8orf2; Erlin-2; NET32; SPFH2; SPG18
Summary	This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

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