Human DR4 (TNFRSF10A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TNFRSF10A
Locus ID	8797
Kit Components	GA105843G1, DR4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105843G2, DR4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105843G3, DR4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_003844
Synonyms	APO2; CD261; DR4; TRAILR-1; TRAILR1
Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]

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