Human VMAT1 (SLC18A1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SLC18A1
Locus ID	6570
Kit Components	GA104489G1, VMAT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104489G2, VMAT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104489G3, VMAT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001135691, NM_001142324, NM_001142325, NM_003053
Synonyms	CGAT; VAT1; VMAT1
Summary	The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

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