Human Calpain 3 (CAPN3) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	CAPN3
Locus ID	825
Kit Components	GA100578G1, Calpain 3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100578G2, Calpain 3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100578G3, Calpain 3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000070, NM_024344, NM_173087, NM_173088, NM_173089, NM_173090, NM_212464, NM_212465, NM_212467, NR_027911, NR_027912
Synonyms	CANP3; CANPL3; LGMD2; LGMD2A; nCL-1; p94
Summary	Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed. [provided by RefSeq, Jul 2008]

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