Pan3 (BC082547) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR208872L4V
- LentiORF®
-
Lenti ORF particles, Pan3 (GFP-tagged) - Mouse PAN3 polyA specific ribonuclease subunit homolog (S, 200ul, >10^7 TU/mL
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CNY 11115.00
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Specifications
| Product Data | |
| Product Name | Pan3 (BC082547) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2700050F09Rik; A430027N15Rik; AU014670 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC082547 |
| ORF Size | 1680 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR208872).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC082547, AAH82547 |
| RefSeq Size | 4194 bp |
| RefSeq ORF | 1682 bp |
| Locus ID | 72587 |
| Gene Summary | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.[UniProtKB/Swiss-Prot Function] |
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