Arhgap8 (BC024991) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR205893L4V
- LentiORF®
-
Lenti ORF particles, Arhgap8 (GFP-tagged) - Mouse Rho GTPase activating protein 8 (cDNA clone MGC:32512 IMAGE:5065129), 200ul, >10^7 TU/mL
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CNY 11115.00
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Specifications
| Product Data | |
| Product Name | Arhgap8 (BC024991) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | MGC32512 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC024991 |
| ORF Size | 1134 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR205893).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC024991, AAH24991 |
| RefSeq Size | 1731 bp |
| RefSeq ORF | 1136 bp |
| Locus ID | 109270 |
| Gene Summary | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer (By similarity).[UniProtKB/Swiss-Prot Function] |
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