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Snai1 (NM_011427) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR203505L2V
- LentiORF®
-
Lenti ORF particles, Snai1 (GFP-tagged) - Mouse snail homolog 1 (Drosophila) (Snai1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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规格
| Cited in 1 publication. |
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经常一起买 (2)
Specifications
| Product Data | |
| Product Name | Snai1 (NM_011427) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | Sna; Sna1; Snail; Snail1 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_011427 |
| ORF Size | 795 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR203505).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011427.2, NP_035557.1 |
| RefSeq Size | 1613 bp |
| RefSeq ORF | 795 bp |
| Locus ID | 20613 |
| Gene Summary | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. The N-terminal SNAG domain competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (in vitro) (By similarity). During EMT, involved with LOXL2 in negatively regulating pericentromeric heterochromatin transcription (PubMed:24239292). SNAI1 recruits LOXL2 to pericentromeric regions to oxidize histone H3 and repress transcription which leads to release of heterochromatin component CBX5/HP1A, enabling chromatin reorganization and acquisition of mesenchymal traits (PubMed:24239292). Associates with EGR1 and SP1 to mediate 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3'. In addition, may also activate the CDKN2B promoter by itself.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Lysyl Oxidase-like Protein LOXL2 Promotes Lung Metastasis of Breast Cancer
,Salvador, F;Martin, A;López-Menéndez, C;Moreno-Bueno, G;Santos, V;Vázquez-Naharro, A;Santamaria, PG;Morales, S;Dubus, PR;Muinelo-Romay, L;López-López, R;Tung, JC;Weaver, VM;Portillo, F;Cano, A;,
Cancer Res.
,PubMed ID 28720577
[SNAI1]
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