Alkbh7 (BC029677) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR202335L4V
- LentiORF®
-
Lenti ORF particles, Alkbh7 (GFP-tagged) - Mouse alkB, alkylation repair homolog 7 (E. coli) (cDNA clone MGC:39017 IMAGE:5364485), 200ul, >10^7 TU/mL
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CNY 7505.00
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Specifications
| Product Data | |
| Product Name | Alkbh7 (BC029677) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 2310045B01Rik; 2510008E23Rik; Abh7; Spata11 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC029677 |
| ORF Size | 639 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR202335).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC029677, AAH29677 |
| RefSeq Size | 718 bp |
| RefSeq ORF | 641 bp |
| Locus ID | 66400 |
| Gene Summary | May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does not display DNA demethylase activity (By similarity). Involved in fatty acid metabolism.[UniProtKB/Swiss-Prot Function] |
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