Nudt16l1 (BC025569) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR201080L3V
- LentiORF®
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Lenti ORF particles, Nudt16l1 (Myc-DDK-tagged) - Mouse nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1 (cDNA clone MGC:35707 IMAGE:5322456),, 200ul, >10^7 TU/mL
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CNY 6650.00
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Specifications
| Product Data | |
| Product Name | Nudt16l1 (BC025569) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 1110001K21Rik; 5330437I08Rik; Sdos |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | BC025569 |
| ORF Size | 453 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR201080).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC025569, AAH25569 |
| RefSeq Size | 1354 bp |
| RefSeq ORF | 455 bp |
| Locus ID | 66911 |
| Gene Summary | Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA.[UniProtKB/Swiss-Prot Function] |
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