ZCCHC3 (NM_033089) Human Untagged Clone
CAT＃: SC320537
ZCCHC3 (untagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3)
CNY 3656.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C20orf99 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_033089.6
GGAGGATGCTGGGAAGGAGGTAAAATGGCCACCGGCGGCGGCGCGGAGGAAGAGAGGAAA
CGGGGGCGGCCGCAGCTTCTGCCCCCCGCGCGGCCCGCGGCCCGGGGCGAGGAGGCCGAC GGCGGCCGCGAGAAGATGGGCTGGGCCCAGGTGGTGAAGAATCTAGCCGAGAAGAAGGGC GAATTCCGCGAGCCGCGGCCGCCGCGGCGGGAGGAGGAAAGCGGCGGCGGTGGAGGGAGC GCCGGGCTCGGCGGCCCCGCGGGCCTGGCGGCGCCGGACCTCGGCGACTTCCCACCGGCT GGCCGCGGGGACCCGAAGGGCCGTCGGAGAGATCCGGCCGGCGAGGCGGTGGACCCCCGC AAAAAGAAGGGCGCTGCGGAGGCGGGCAGGAGGAAGAAGGCCGAGGCGGCGGCGGCCGCC ATGGCGACCCCGGCCAGGCCCGGCGAGGCCGAGGACGCGGCCGAGCGGCCCCTCCAGGAT GAGCCGGCGGCGGCGGCAGGCCCGGGCAAGGGTCGCTTCCTCGTCCGCATCTGTTTCCAG GGAGACGAGGGCGCCTGCCCGACCCGGGACTTCGTGGTAGGAGCGCTTATCCTGCGCTCC ATCGGCATGGACCCGAGCGACATCTACGCGGTCATCCAGATCCCGGGCAGCCGCGAATTC GACGTGAGCTTCCGCTCAGCGGAGAAGCTGGCCCTGTTCCTACGCGTCTACGAGGAGAAG CGGGAGCAGGAGGACTGCTGGGAGAACTTTGTGGTGCTGGGGCGGAGCAAGTCCAGCTTG AAGACGCTCTTCATCCTCTTCCGGAACGAGACGGTGGACGTGGAGGACATTGTGACTTGG CTCAAGCGCCACTGCGACGTGCTGGCCGTGCCGGTGAAAGTGACCGACAGGTTTGGGATC TGGACCGGGGAGTACAAATGCGAGATCGAGCTGCGCCAGGGGGAGGGCGGGGTCAGGCAC TTGCCAGGGGCCTTCTTCCTGGGGGCCGAGAGGGGCTACAGCTGGTACAAGGGGCAGCCC AAGACATGCTTTAAATGTGGTTCCCGGACCCACATGAGCGGCAGCTGCACGCAGGACAGG TGCTTCAGGTGCGGGGAGGAGGGGCACCTGAGCCCTTACTGCCGGAAGGGCATCGTGTGC AACCTCTGTGGCAAGCGAGGACACGCCTTTGCCCAGTGTCCCAAAGCAGTGCACAATTCC GTGGCAGCTCAGCTAACCGGCGTGGCCGGGCACTAAACACCCGCCTGCCTGCCAGGGTGA ACACACAGCCAGCTTATCCCTCTTAAGTGCCAAAACTTTTTTTTAAACCATTTTTTATCG TTTTTGAAGGAGATCTTTTTAAAACCTACAAGAGACATCTCTCTATGCCTTCTTAAACCG AGTTTACTCCATTTCAGCCTGTTCTGAATTGGTGACTCTGTCACCAATAACGACTGCGGA GAACTGTAGCGTGCAGATGTGTTGCCCCTCCCTTTTAAAATTTTATTTTCGTTTTTCTAT TGGGTATTTGTTTTGTTTCTTGTACTTTTTCTCTCTCTCCTTGCCCCCCTCCCGCCCTCC CCGCCCCATACCTTTTCTTCCCCTGGATTTTCACCCTTTGGGCTGCCTTGCTCATCTTTA TGCCCCAGCACTAGGTACGGGGCCCAACACGTGGTAGGCACTCCATCAGTGTTTGCTGAA TTGAAAACATTGTTGACTGTGGCTTCTATCAGAGTGTCTACCTTTTGCAGCTCTTCCCCT CCCTCATTTAATTTGCTGCTTTTAATCTACGTGGTCTGAGAATTTGTGAAACCAGTGTTG TTAGAAGTGTATATAATCTGAATCAATAAGCTCTGAATGGTGGCCAAGGGCCTCTCTTAT GGCACAAAGATGCATGGACTTCATGACAGCTCTTTTGGTGGCTCAGAAGCCATTTTTTAT AGAATCATGGAATCTAGAATATTCCTGCTGGAAAGAACCTGAGAGTTGGTTTGGACCAAT TCCCTGGTTTTCCAGCAGATGAAACAGGCCCAAAGAGGTTAAATGACTGGGTGAAAATCA CATAGCTGTCTGGTGCCAGAGCCAGCCTATAGTAGAGTCCCCTGACCCCAAGCCCGGTGC TCATTCCACTACCTCTCACACTTCACAACAATTTCCTCAACACTTGAGGGCCCAGAAAGT CTGATCTCTCCAGAATGATCAGCCCAGAGGAATGCTGAGAAATCACCTGGAGGAGGGAGC AGAAAGAGAAGGTTTTTAAGGAGGGGCTTCTGAATACTTGGGAGATACGGAACGGACCAA GGACCACACTCCAGGGTGCATTCGTTGCTCCCTGGGGCACCACTTCTGGATTACAGTGTG CCAGGTCCTTTGGAGGCCCTACCCCTTCCCCATTCATTGCCACCAGTGAGAAATGGGGGT GCCCCTGTGTAAAGAAACCTACCAAAGGTTTACATTTGCACCTTAGCCTCAATAGCTACG AACCCTAGAGAAGCAGCTAGCTGGAGCTCATGTGCAACTCCTGATTCTCAGGAGAAAGAT GGATTTTAACCCAAAATTATGAGTGAGCTGTTAACTCTAAAATGTACTTGGGAGATAGGC CAAGCGAGAGGTCATGGGCCAACTAAGTGTTATCCAGTAGAAAAGACAGTACACTGCTTT TCTTTTAGTGTTTGCTTTTCCTTTGCTATATGTTTTGCTATTTCCTTGTGGCTTAGAATG TAAAATTGATTGTTAAAAGTTTTGTTCTGAATAAATATTTATCTTTTGTATTGCTAAAAA AAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_033089 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_033089.6, NP_149080.2 |
| RefSeq Size | 2773 bp |
| RefSeq ORF | 1212 bp |
| Locus ID | 85364 |
| UniProt ID | Q9NUD5 |
| Domains | zf-CCHC |
| Gene Summary | Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209646 | ZCCHC3 (Myc-DDK-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 3656.00 |
|
| RC209646L3 | Lenti-ORF clone of ZCCHC3 (Myc-DDK-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 5890.00 |
|
| RC209646L4 | Lenti-ORF clone of ZCCHC3 (mGFP-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 5890.00 |
|
| RG209646 | ZCCHC3 (tGFP-tagged) - Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 4370.00 |
|
| SC101625 | ZCCHC3 (untagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 3656.00 |
