ZCCHC3 (NM_033089) Human Untagged Clone
CAT＃: SC101625
ZCCHC3 (untagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3)
CNY 3656.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C20orf99 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_033089, the custom clone sequence may differ by one or more nucleotides
ATGGCCACCGGCGGCGGCGCGGAGGAAGAGAGGAAACGGGGGCGGCCGCAGCTTCTGCCCCCCGCGCGGC CCGCGGCCCGGGGCGAGGAGGCCGACGGCGGCCGCGAGAAGATGGGCTGGGCCCAGGTGGTGAAGAATCT AGCCGAGAAGAAGGGCGAATTCCGCGAGCCGCGGCCGCCGCGGCGGGAGGAGGAAAGCGGCGGCGGTGGA GGGAGCGCCGGGCTCGGCGGCCCCGCGGGCCTGGCGGCGCCGGACCTCGGCGACTTCCCACCGGCTGGCC GCGGGGATCCGAAGGGCCGTCGGAGAGATCCGGCCGGCGAGGCGGTGGACCCCCGCAAAAAGAAGGGCGC TGCGGAGGCGGGCAGGAGGAAGAAGGCCGAGGCGGCGGCGGCCGCCATGGCGACCCCGGCCAGGCCCGGC GAGGCCGAGGACGCGGCCGAGCGGCCCCTCCAGGATGAGCCGGCGGCGGCGGCAGGCCCGGGCAAGGGTC GCTTCCTCGTCCGCATCTGTTTCCAGGGAGACGAGGGCGCCTGCCCGACCCGGGACTTCGTGGTAGGAGC GCTTATCCTGCGCTCCATCGGCATGGACCCGAGCGACATCTACGCGGTCATCCAGATCCCGGGCAGCCGC GAATTCGACGTGAGCTTCCGCTCAGCGGAGAAGCTGGCCCTGTTCCTACGCGTCTACGAGGAGAAGCGGG AGCAGGAGGACTGCTGGGAGAACTTTGTGGTGCTGGGGCGGAGCAAGTCCAGCTTGAAGACGCTCTTCAT CCTCTTCCGGAACGAGACGGTGGACGTGGAGGACATTGTGACTTGGCTCAAGCGCCACTGCGACGTGCTG GCCGTGCCGGTGAAAGTGACCGACAGGTTTGGGATCTGGACCGGGGAGTACAAATGCGAGATCGAGCTGC GCCAGGGGGAGGGCGGGGTCAGGCACTTGCCAGGGGCCTTCTTCCTGGGGGCCGAGAGGGGCTACAGCTG GTACAAGGGGCAGCCCAAGACATGCTTTAAATGTGGTTCCCGGACCCACATGAGCGGCAGCTGCACGCAG GACAGGTGCTTCAGGTGCGGGGAGGAGGGGCACCTGAGCCCTTACTGCCGGAAGGGCATCGTGTGCAACC TCTGTGGCAAGCGAGGACACGCCTTTGCCCAGTGTCCCAAAGCAGTGCACAATTCCGTGGCAGCTCAGCT AACCGGCGTGGCCGGGCACTAA >OriGene 5' read for NM_033089 unedited
TATACGACTCACTATAGGCGGCCCGCGAATTCGCACGAGAAAAGAGGTAAAATGGCCACC GGCGGCGGCGCGGAGGAAGAGAGGAAACGGGGGCGGCCGCAGCTTCTGCCCCCCGCGCGG CCCGCGGCCCGGGGCGAGGAGGCCGACGGCGGCCGCGAGAAGATGGGCTGGGCCCAGGTG GTGAAGAATCTAGCCGAGAAGAAGGGCGAATTCCGCGAGCCGCGGCCGCCGCGGCGGGAG GAGGAAAGCGGCGGCGGTGGAGGGAGCGCCGGGCTCGGCGGCCCCGCGGGCCTGGCGGCG CCGGACCTCGGCGACTTCCCACCGGCTGGCCGCGGGGACCCGAAGGGCCGTCGGAGAGAT CCGGCCGGCGAGGCGGTGGACCCCCGCAAAAAGAAGGGCGCTGCGGAGGCGGGCAGGAGG AAGAAGGCCGAGGCGGCGGCGGCCGCCATGGCGACCCCGGCCAGGCCCGGCGAGGCCGAG GACGCGGCCGAGCGGCCCCTCCAGGATGAGCCGGCGGCGGCGGCAGGCCCGGGCAAGGGT CGCTTCCTCGTCCGCATCTGTTTCCAGGGAGACGAGGGCGCCTGCCCGACCCGGGACTTC GTGGTAGGAGCGCTTATCCTGCGCTCCATCGGCATGGACCCGAGCGACATCTACGCGGTC ATCCAGATCCCGGGCAGCCGCGAATTCGACGTGAGCTTCCGCTCAGCGGAGAAGCTGGCC CTGTTCCTACGCGTCTACGAGGAGAAGCGGGAGCAGGAGGACTGCTGGGAGAACTTTGTG GTGCTGGGGCGGAGCAAGTCCAGCTTGNAGACGCTCTTCATCCTCTTNCGAACGANGACG TGGACGTGNAGGACATTGTGACTTGGCTCAAGCGCACTGCGACGTGCTGGGCCGTGCCGT GAAAGTGACCGACAGGTTTGGGATCTGGACCCGGGGGTCAAATGCAAATCACCTGCGCAG GGGAGGGCCGGGTCAGCACTGCCAGGGCCT >OriGene 3' read for NM_033089 unedited
TAGTACCGCGCCGCTATCTANGATCGAGTTTTTTTTTTTTTTTTTTGGCAATACAAAAGA TAAATATTTATTCAGAACAAAACTTTTAACAATCAATTTTACATTCTAAGCCACAAGGAA ATAGCAAAACATATAGCAAAGGAAAAGCAAACACTAAAAGAAAAGCAGTGTACTGTCTTT TCTACTGGATAACACTTAGTTGGCCCATGACCTCTCGCTTGGCCTATCTCCCAAGTACAT TTTAGAGTTAACAGCTCACTCATAATTTTGGGTTAAAATCCATCTTTCTCCTGAGAATCA GGAGTTGCACATGAGCTCCAGCTAGCTGCTTCTCTAGGGTTCGTAGCTATTGAGGCTAAG GTGCAAATGTAAACCTTTGGTAGGTTTCTTTACACAGGGGCACCCCCATTTCTCACTGGT GGCAATGAATGGGGAAGGGGTAGGGCCTCCAAAGGACCTGGCACACTGTAATCCAGAAGT GGTGCCCCAGGGAGCAACGAATGCACCCTGGAGTGTGGTCCTTGGTCCGTTCCGTATCTC CCAAGTATTCAGAAGCCCCTCCTTAAAAACCTTCTCTTTCTGCTCCCTCCTCCAGGTGAT TTCTCAGCATTCCTCTGGGCTGATCAATTCTGGAGAGATCAGACTTTCTGGGCCCCTCAA GTGTGAAGAAATTGNTGTGAATTGTGAGAAGTANTGGAATGAGCACCCGGGCTGGNNGTC AGGGACTCTACTATAGGCTGGCTCTGGCACCGACAGCTATGTGATTTTCACCCGTCCATT TACCTCTTTTGGCCCGTTTCATCTGCTGGGAAAACCAGGGAATGGTCCAAAACAACTCTC AAGTCCTTTCCAGCAGAAAAATCTAAATCCAGGAATCATTAAAAATGGGTTCTGGACCAC CAAAAAACTGGCTGAAGTCCAGCTTCTTGTGCCATAGAAAGCCCCTGGCCCCATTAGAAT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_033089 |
| Insert Size | 2380 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_033089.6, NP_149080.2 |
| RefSeq Size | 2773 bp |
| RefSeq ORF | 1212 bp |
| Locus ID | 85364 |
| UniProt ID | Q9NUD5 |
| Domains | zf-CCHC |
| Gene Summary | Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses (PubMed:30193849, PubMed:30135424). Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS (PubMed:30193849, PubMed:30135424). Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (PubMed:30135424). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and activation (PubMed:30135424). Promotes sensing of viral RNA by RIG-I-like receptors proteins DDX58/RIG-I and IFIH1/MDA5 via two mechanisms: binds double-stranded RNA (dsRNA), enhancing the binding of DDX58/RIG-I and IFIH1/MDA5 to dsRNA and promotes 'Lys-63'-linked ubiquitination and subsequent activation of DDX58/RIG-I and IFIH1/MDA5 (PubMed:30193849).[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209646 | ZCCHC3 (Myc-DDK-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 3656.00 |
|
| RC209646L3 | Lenti-ORF clone of ZCCHC3 (Myc-DDK-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 5890.00 |
|
| RC209646L4 | Lenti-ORF clone of ZCCHC3 (mGFP-tagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 5890.00 |
|
| RG209646 | ZCCHC3 (tGFP-tagged) - Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 4370.00 |
|
| SC320537 | ZCCHC3 (untagged)-Human zinc finger, CCHC domain containing 3 (ZCCHC3) |
CNY 3656.00 |
