TAB2 (NM_015093) Human Untagged Clone
CAT＃: SC111198
TAB2 (untagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2)
CNY 7624.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CHTD2; MAP3K7IP2; TAB-2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_015093, the custom clone sequence may differ by one or more nucleotides
ATGGCCCAAGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGTAC CTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTGTGCTGTTCTCTC TCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTCAGATGATTCTGGAATTTCTGGT CTACGCAATCACATGACTTCTCTCAACTTGGACTTGCAATCACAGAACATTTACCACCATGGAAGAGAAG GAAGTAGGATGAATGGAAGTAGGACTCTAACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTC CAATAGTGAACTATTTCAGCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTT GGAATGTCCAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGGAA CATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCCAAATATCCAGAC TGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACCTGTACTTAACAGTCCACAGGGA AATTCTATCTATATTAGGCCTTACATTACAACTCCTGGTGGTACAACTCGACAGACACAACAGCATTCTG GCTGGGTATCTCAGTTTAATCCCATGAACCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGAC TACTTGTCCTGCATCTAATCCTCTGTCACATACCTCATCTCAACAGCCAAATCAGCAAGGCCACCAGACC TCTCATGTCTACATGCCAATCAGTTCACCTACTACTTCACAACCACCAACCATTCATTCATCTGGTAGCT CACAGTCTTCTGCCCATAGCCAATATAACATTCAGAATATTTCAACAGGACCTCGAAAAAACCAGATTGA AATCAAACTTGAACCCCCACAAAGAAATAATTCTTCAAAACTGCGTTCTTCTGGACCTCGAACCTCCAGC ACTTCCTCTTCAGTCAATAGCCAGACCTTAAACAGAAATCAGCCCACTGTTTACATAGCTGCCAGCCCCC CAAATACGGATGAGCTGATGTCCCGTAGTCAACCTAAGGTCTATATTTCAGCGAATGCTGCCACAGGAGA TGAACAGGTCATGCGGAATCAGCCCACACTCTTCATATCCACAAACTCTGGAGCATCTGCTGCCTCCAGG AACATGTCTGGGCAAGTGAGCATGGGTCCTGCCTTTATTCATCACCATCCTCCCAAAAGTCGAGCAATAG GCAATAACTCTGCAACCTCTCCTCGAGTGGTAGTCACTCAGCCCAATACGAAATACACTTTCAAAATTAC AGTCTCTCCCAATAAGCCCCCTGCAGTTTCACCAGGGGTGGTGTCCCCTACCTTTGAACTTACAAATCTT CTTAATCATCCTGATCATTATGTAGAAACCGAGAATATTCAGCACCTCACGGACCCTACATTAGCACATG TGGATAGAATAAGTGAAACACGGAAACTGAGTATGGGATCTGATGATGCTGCCTACACACAAGCTCTTTT GGTACACCAGAAGGCCAGAATGGAACGACTTCAAAGAGAACTTGAGATTCAAAAGAAAAAGCTGGATAAA TTAAAATCTGAGGTTAATGAAATGGAAAATAATCTAACTCGAAGGCGCCTGAAAAGATCAAATTCTATAT CCCAGATACCTTCCCTTGAAGAAATGCAGCAGCTGAGAAGTTGTAATAGACAACTCCAGATTGACATTGA CTGCTTAACCAAAGAAATTGATCTTTTTCAAGCCCGAGGACCACATTTTAACCCCAGCGCTATTCATAAC TTTTATGACAATATTGGATTTGTAGGTCCTGTGCCACCAAAACCCAAAGATCAAAGGTCCATCATCAAAA CACCAAAGACTCAAGACACAGAAGATGATGAGGGAGCTCAGTGGAATTGTACCGCCTGTACTTTTTTGAA CCATCCAGCCTTAATTCGCTGTGAACAGTGTGAGATGCCAAGGCATTTCTGA >OriGene 5' read for NM_015093 unedited
NGGGTCGAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACCAGGATGGCCCA AGGAAGCCACCAAATTGATTTTCAGGTTTTACATGACCTGCGACAAAAATTCCCTGAAGT ACCTGAAGTTGTTGTATCCAGGTGCATGTTACAGAATAATAATAACCTGGATGCCTGCTG TGCTGTTCTCTCTCAGGAGAGTACAAGATATCTTTATGGTGAAGGAGACTTGAATTTTTC AGATGATTCTGGAATTTCTGGTCTACGCAATCACATGACTTCTCTCAACTTGGACTTGCA ATCACAGAACATTTACCACCATGGAAGAGAAGGAAGTAGGATGAATGGAAGTAGGACTCT AACGCACAGCATTAGTGATGGACAACTTCAAGGTGGCCAGTCCAATAGTGAACTATTTCA GCAGGAGCCACAGACAGCACCAGCTCAAGTTCCTCAAGGCTTTAATGTTTTTGGAATGTC CAGTTCCTCTGGTGCTTCAAATTCAGCACCACATCTTGGATTTCACTTAGGCAGCAAAGG AACATCTAGCCTTTCTCAACAAACTCCCAGATTTAATCCCATTATGGTAACTTTAGCCCC AAATATCCAGACTGGTCGTAATACTCCTACATCTTTGCACATACATGGTGTACCTCCACC TGTACTTAACAGTCCACAGGGAAATTCTATCTATATTAGGCCTTACATTACAACTCCTGG TGGTACAACTCGACAGACACAACAGCATTCTGGCTGGGTATCTCAGTTTAATCCCATGAA CCCTCAGCAAGTTTATCAGCCTTCACAGCCTGGTCCCTGGACTACTTGTCCTGCATCTAA TNCTCTGTCACATACCTCATCTCACAGCCAAATCAGCAGGGCCCCAGACCTCTCATGTCT ACTGC >OriGene 3' read for NM_015093 unedited
NAATACTCTGNNACCGCGNNCCGCATTCTAGNGATCGAGTTTTTTTTTTTTTTTTTTTTT CAAAATATCCAAATTACGTTTTATTAATAAAACAAGTAAAAACTGATTTATCAATCTTCA CATAAAACTGCAGATGAAGCTGAAAAACAAGGCCTATTTTAAAAATAAATTGCATCAAAC GTAAGGGCTTTGGGTCTATGGTTTAATTACCTAGGATTGTCATATTTCTTCCCATATACA AAATGCAAAGCCTGAAAGTTAGGGCTCTGACATTCATAGAGATCAACTGTAATAATCCCA TTTAAAACACAGCCACTTGCAAACATTTACAGGGGGTGGTAGTCTATATTATCTTCCATC CTTTGCTCTATTTCAGCACTTCCCTTAGCCCCATTCTAAGCACTCATATAATTTCATAAT TCTGCCTTTTTAAATGCATACTGTTCTTTTTCTTGATTTCAGTTATATACCTTCCTGATC ATCTGAATATTTTCCTTACAAAAATATTTTATCAAAATAAAGAGATGCTTGAGGTTGCTT CCATGTTCAAGTTCGCTCGGTCTTTTTTTCACGCTTCCCTCCATCTTGTTTAATACGCCA GCCCTTGCCTTATAAATCCCTTTATCCTGTCCCCCCCCCTCGTTCATTATTGCCTTCCCC TCCCCATAACTCTCTTAAACTTCTTCTCCCATACTCCGGTCCCCTTTCTCCCTCCTTCTT TTCGCTCTTAACCCCGTATCTATCTATAATCCCCCGCTCCTCTTTCCCCCCCTCCCATTA TCCACACCACATTCTATATCTTCCCCTTTCCCTATCCTATTTTCCCTCCTTCTTCTTTTT CCCTCCTTTTTTCCCCCTCCTCTTTCCTCTTCATTTTCTTAAATCCTTTTCTTTTCCCTC CCTCCTCTTCTTCTGTTTTCTCCCCCATTTCTCGACCCTCTCCTCCTCCCCCACCTCTTC CCACC |
| Restriction Sites | ECoRI-NOT |
| ACCN | NM_015093 |
| Insert Size | 3670 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_015093.2, NP_055908.1 |
| RefSeq Size | 4149 bp |
| RefSeq ORF | 2082 bp |
| Locus ID | 23118 |
| UniProt ID | Q9NYJ8 |
| Domains | zf-RanBP, CUE |
| Protein Families | Druggable Genome |
| Protein Pathways | MAPK signaling pathway, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway |
| Gene Summary | The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode isoform a. |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex
,Lei, X;Han, N;Xiao, X;Jin, Q;He, B;Wang, J;,
J. Virol.
,PubMed ID 24942571
[TAB2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC207721 | TAB2 (Myc-DDK-tagged)-Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) |
CNY 7616.00 |
|
| RC207721L1 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), Myc-DDK-tagged |
CNY 10016.00 |
|
| RC207721L2 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), mGFP tagged |
CNY 7700.00 |
|
| RC207721L3 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), Myc-DDK-tagged |
CNY 7700.00 |
|
| RC207721L4 | Lenti ORF clone of Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2), mGFP tagged |
CNY 10016.00 |
|
| RG207721 | TAB2 (tGFP-tagged) - Human TGF-beta activated kinase 1/MAP3K7 binding protein 2 (TAB2) |
CNY 9216.00 |
