SIRT1 Mouse Monoclonal Antibody [Clone ID: OTI12H3]

Specifications

Product Data
Clone Name	OTI12H3
Applications	WB
Recommend Dilution	WB 1:2000
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 552-676 of human SIRT1(NP_036370) produced in E.coli.
Isotype	IgG2b
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	81.5 kDa
Gene Name	sirtuin 1
Database Link	NP_036370 Entrez Gene 93759 MouseEntrez Gene 309757 RatEntrez Gene 23411 Human UniProt ID Q96EB6
Background	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Synonyms	SIR2; SIR2alpha; SIR2L1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors

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