TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]

Specifications

Product Data
Clone Name	OTI10H5
Applications	IHC, Simple Western, WB
Recommend Dilution	WB 1:5000~10000, IHC 1:50; Simple Western 1:20-1:50
Reactivity	Human, Dog, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Isotype	IgG1
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	134.3 kDa
Gene Name	transient receptor potential cation channel subfamily M member 4
Database Link	NP_060106 Entrez Gene 484385 DogEntrez Gene 719120 MonkeyEntrez Gene 54795 Human UniProt ID Q8TD43
Background	Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Synonyms	hTRPM4; LTrpC4; PFHB1B; TRPM4B
Reference Data
Protein Families	Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

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