NLRP3 Rabbit Polyclonal Antibody
CNY 5070.00
| Cited in 1 publication. |
Product images
CNY 4840.00
CNY 300.00
CNY 1430.00
CNY 2900.00
CNY 9998.00
Specifications
| Product Data | |
| Applications | WB |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Specificity | Expected reactivity: Cow, Dog, Horse, Human, Pig, Rabbit Homology: Cow: 93%; Dog: 79%; Horse: 93%; Human: 100%; Pig: 93%; Rabbit: 79% |
| Formulation | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage Condition | For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Predicted Protein Size | 114kDa |
| Gene Name | NLR family, pyrin domain containing 3 |
| Database Link | |
| Background | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). |
| Synonyms | AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; cryopyrin; FCAS; FCU; FLJ95925; MWS; NALP3; PYPAF1 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | NOD-like receptor signaling pathway |
Citations (1)
| The use of this Antibodies has been cited in the following citations: |
|---|
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Thioredoxin-interacting protein: a potential therapeutic target for treatment of progressive fibrosis in diabetic nephropathy.
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Nephron
,PubMed ID 25662516
[NLRP3]
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