UHRF1 Mouse Monoclonal Antibody [Clone ID: 1H9-D3-E11]

Specifications

Product Data
Clone Name	1H9-D3-E11
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for UHRF1 antibody: purified recombinant human UHRF1 protein fragments expressed in E.coil.
Isotype	IgG2b
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	90 kDa
Gene Name	ubiquitin like with PHD and ring finger domains 1
Database Link	NP_037414 Entrez Gene 18140 MouseEntrez Gene 29128 Human UniProt ID Q96T88
Background	This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	hNP95; hUHRF1; huNp95; ICBP90; Np95; RNF106
Note	Detects ~ 38kDa.
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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