RPA34 (RPA2) Mouse Monoclonal Antibody [Clone ID: 3E7-B5-F2]

Specifications

Product Data
Clone Name	3E7-B5-F2
Applications	IF, IP, WB
Recommend Dilution	WB: 1:2000, IF: 1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for RPA2 antibody: purified recombinant human RPA32/RPA2 protein fragments expressed in E.coli.
Isotype	IgG2b
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	32 kDa
Gene Name	replication protein A2
Database Link	NP_002937 Entrez Gene 6118 Human UniProt ID P15927
Background	Required for DNA recombination,repair and replication.The activity of RP-A is mediated by single-stranded DNA binding and protein interactions.Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage.Functions as component of the alternative replication protein A complex (aRPA).aRPA binds single-stranded DNA and probably plays a role in DNA repair;it does not support chromosomal DNA replication and cell cycle progression through S-phase.In vitro,aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC),the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Synonyms	REPA2; RP-A p32; RP-A p34; RPA32
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	DNA replication, Homologous recombination, Mismatch repair, Nucleotide excision repair

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