PRMT6 Mouse Monoclonal Antibody [Clone ID: 2C3-F1-G1]

Specifications

Product Data
Clone Name	2C3-F1-G1
Applications	IF, IHC, WB
Recommend Dilution	WB: 1:1000, IF: 1:300
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for PRMT6 antibody: purified recombinant human PRMT6 protein fragments expressed in E.coli.
Isotype	IgG1
Formulation	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	protein arginine methyltransferase 6
Database Link	NP_060607 Entrez Gene 55170 Human UniProt ID Q96LA8
Background	PRMT6 is a protein arginine N-methyltransferase, and catalyzes the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation is a prevalent post-translational modification in eukaryotic cells that has been implicated in signal transduction, the metabolism of nascent pre-RNA, and the transcriptional activation processes. IPRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition, PRMT6 displays automethylation activity; it is the first PRMT to do so. PRMT6 has been shown to act as a restriction factor for HIV replication.
Synonyms	HRMT1L6
Reference Data
Protein Families	Druggable Genome

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