MYD88 Mouse Monoclonal Antibody [Clone ID: 4D6]

Specifications

Product Data
Clone Name	4D6
Applications	CyTOF-ready, FC, ICC/IF, WB
Recommend Dilution	Flow (Intracellular), Western Blot: 2 ug/ml, Flow Cytometry: 0.5ug/10^6cells~, Immunocytochemistry/ Immunofluorescence: 5ug/ml, CyTOF-ready
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A portion of amino acids 50-100 of human MyD88 was used as the immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	myeloid differentiation primary response 88
Database Link	NP_002459 Entrez Gene 4615 Human UniProt ID Q99836
Background	MyD88, a protein involved in interleukin-1 (IL-1) mediated signalling was originally isolated as myeloid differentiation primary response gene (3,4). MyD88 possesses a N-terminal death domain similar to cytoplasmic segments of TNF receptor 1, Fas, and C-terminal region related to IL-1 and Toll receptors. Overexpression of MyD88 induces activation the c-Jun N-terminal kinase and NF-kB through its death domain (1,2). The C-terminus of MyD88 interacts with the IL-1 receptor and blocks NF-kB activation induced by IL-1, but not by NF-kB.
Synonyms	MYD88D
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Apoptosis, Toll-like receptor signaling pathway

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