Calnexin (CANX) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000
Reactivity	Human, Monkey, Mouse, Rat, Bovine, Dog, Hamster, Rabbit, Pig, Quail, Sheep, Xenopus (weak), Guinea Pig, Drosophila (weak), Chicken (weak)
Host	Rabbit
Clonality	Polyclonal
Immunogen	Dog Calnexin C-terminal synthetic peptide conjugated to KLH. Identical to human, mouse and rat calnexin sequences over these residues.
Formulation	PBS pH7.2, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein A Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calnexin
Database Link	NP_001737 Entrez Gene 12330 MouseEntrez Gene 29144 RatEntrez Gene 403908 DogEntrez Gene 704794 MonkeyEntrez Gene 821 Human UniProt ID P27824
Background	Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 . It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail . Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention , calnexin has positively charged cytosolic residues that do the same thing . Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptides and their assembly into mulitsubunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglycosylated glycans . Calnexin has also been shown to associate with the major histocompatability complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin .
Synonyms	CNX; IP90; P90
Note	Detects ~90kDa.
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Antigen processing and presentation

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