SPIN2B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cell lysate IHC: 50-200 Positive control: Human liver cancer Predicted cell location: Nucleus and Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full length fusion protein
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	29 kDa
Gene Name	spindlin family member 2B
Database Link	NP_001006682 Entrez Gene 474343 Human UniProt ID Q9BPZ2
Background	Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal; but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary; SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also; SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells; SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M; which was more pronounced following IL3 withdrawal.
Synonyms	dJ323P24.2; SPIN-2; SPIN-2B; SPIN2_duplicate; TDRD26
Reference Data

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