TrkA (NTRK1) Rabbit Polyclonal Antibody
CAT＃: TA322998S
Anti-NTRK1 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 300.00
CNY 1430.00
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CNY 4840.00
Specifications
| Product Data | |
| Applications | IHC |
| Recommend Dilution | IHC: 100-300 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 781-796 amino acids of human neurotrophic tyrosine kinase, receptor, type 1 |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Gene Name | neurotrophic receptor tyrosine kinase 1 |
| Database Link | |
| Background | This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that; upon neurotrophin binding; phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain; anhidrosis; self-mutilating behavior; mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found; but only three have been characterized to date. |
| Synonyms | MTC; p140-TrkA; TRK; Trk-A; TRK1; TRKA |
| Reference Data | |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Apoptosis, Endocytosis, MAPK signaling pathway, Neurotrophin signaling pathway, Pathways in cancer, Thyroid cancer |
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