RAD50 Rabbit Polyclonal Antibody
CAT＃: TA321721S
Anti-RAD50 Rabbit Polyclonal Antibody
Size: 100 ul
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CNY 800.00
CNY 1280.00
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CNY 300.00
CNY 1430.00
Specifications
| Product Data | |
| Applications | IHC, WB |
| Recommend Dilution | WB: 500-2000 WB positive control: 293T, Hela, K562, NIH/3T3 and RAW264.7 cells IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm, Nucleus |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 325-339 amino acids of Human RAD50 homolog (S. cerevisiae) |
| Isotype | IgG |
| Formulation | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 154 kDa |
| Gene Name | RAD50 double strand break repair protein |
| Database Link | |
| Background | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50; a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein; cooperating with its partners; is important for DNA double-strand break repair; cell cycle checkpoint activation; telomere maintenance; and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. |
| Synonyms | hRad50; NBSLD; RAD502 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Homologous recombination, Non-homologous end-joining |
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