RAD50 Rabbit Polyclonal Antibody [Clone ID: zinc hook domain]

Specifications

Product Data
Clone Name	zinc hook domain
Applications	Simple Western, WB
Recommend Dilution	Immunoprecipitation: 1-5ul, Western Blot: 1:1000-1:10000, Simple Western: 1:1000
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Human Rad50 zinc hook region (amino acids 628-787) expressed in E. coli.
Isotype	IgG
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RAD50 double strand break repair protein
Database Link	NP_005723 Entrez Gene 10111 Human UniProt ID Q92878
Background	Rad50, a 153kDa protein, is associated with Mre11 and Nbs1 (Nibrin or p95) to form a multiprotein complex involved in the double strand break repair process. Rad50 is a member of the family of structural maintenance of chromosome (SMC) proteins. Members of this family share similar structures consisting of globular N- and C-termini separated by a coiled-coil domain. At the base of the coiled-coil region is a zinc binding motif, the zinc hook. The zinc hook mediates Rad50 dimerization through the linkage of two Rad50 coiled-coil tails.
Synonyms	hRad50; NBSLD; RAD502
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Homologous recombination, Non-homologous end-joining

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