TWEAKR (TNFRSF12A) Mouse Monoclonal Antibody [Clone ID: ITEM-4]

Specifications

Product Data
Clone Name	ITEM-4
Applications	FC
Recommend Dilution	Flow cytometry.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CD266-transfected P815 cells
Specificity	This antibody recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Isotype	IgG2b
Formulation	Phosphate buffered saline (PBS) Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	tumor necrosis factor receptor superfamily member 12A
Database Link	Entrez Gene 51330 Human UniProt ID Q9NP84
Background	CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Synonyms	FGF-inducible 14, FN14, TNFRSF12A, Tweak receptor
Reference Data

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