TWEAKR (TNFRSF12A) Mouse Monoclonal Antibody [Clone ID: ITEM-4]

Specifications

Product Data
Clone Name	ITEM-4
Applications	FC, FN, IHC, WB
Recommend Dilution	Flow cytometry. Western blot. Immunohistochemistry (frozen sections). Functional application (blocking).
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CD266-transfected P815 cells
Specificity	This antibody recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
Isotype	IgG2b
Formulation	Phosphate buffered saline (PBS) State: Purified State: Liquid Ig fraction Preservative: 15 mM sodium azide, approx. pH 7.4
Concentration	lot specific
Purification	Protein-A affinity chromatography (> 95% pure by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	tumor necrosis factor receptor superfamily member 12A
Database Link	Entrez Gene 51330 Human UniProt ID Q9NP84
Background	CD266 / TWEAK R (TNFRSF12A), also known as FN14 (fibroblast growth factor-inducible 14) is a receptor for CD255 / TWEAK, the TNF-like weak inducer of apoptosis. CD266 is expressed on endothelial cells, as well as on some cancer tissues, and plays a role in CD255-induced endothelial cell migration, proliferation, and angiogenesis. The CD255-CD266 interaction, or antibody-mediated triggering of CD266 is also able to induce apoptosis and necrosis in CD266-positive cells (including tumor cells), which might have therapeutic potential.
Synonyms	FGF-inducible 14, FN14, TNFRSF12A, Tweak receptor
Reference Data

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