ENPP3 Mouse Monoclonal Antibody [Clone ID: NP4D6]

Specifications

Product Data
Clone Name	NP4D6
Applications	FC, IF
Recommend Dilution	Flow Cytometry analysis of Human blood cells using 20 µl reagent/100 ml of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Immunofluorescence.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	HEK-293 cells transfected with Human CD203c
Specificity	The antibody NP4D6 reacts with CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Isotype	IgG1
Formulation	PBS Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% high-grade protease free BSA as a stabilizing agent Preservative: 15 mM Sodium Azide Label: Conjugated with R-Phycoerythrin under optimum conditions
Purification	Size-Exclusion Chromatography
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!. This antibody is photosensitive and should be protected from light.
Gene Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Database Link	Entrez Gene 5169 Human UniProt ID O14638
Background	CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.
Synonyms	E-NPP 3, PDNP3, Phosphodiesterase I beta, PD-I beta
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Metabolic pathways, Nicotinate and nicotinamide metabolism, Pantothenate and CoA biosynthesis, Purine metabolism, Riboflavin metabolism, Starch and sucrose metabolism

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