CD24 Mouse Monoclonal Antibody [Clone ID: SN3]

Specifications

Product Data
Clone Name	SN3
Applications	FC, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry (frozen sections). Positive tissue: tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Glycoproteins purified from human NALM-1 cell line
Specificity	The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
Isotype	IgG1
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative State: Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Protein A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD24 molecule
Database Link	Entrez Gene 100133941 Human UniProt ID P25063
Background	CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
Synonyms	X62 heat stable antigen, HSA
Reference Data

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