CD24 Mouse Monoclonal Antibody [Clone ID: SN3]

Specifications

Product Data
Clone Name	SN3
Applications	FC
Recommend Dilution	Flow Cytometry (human blood cells using 20 ?l reagent / 100 ?l of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Glycoproteins purified from human NALM-1 cell line
Specificity	The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
Isotype	IgG1
Formulation	Phosphate buffered saline (PBS) containing 15 mM Sodium Azide Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use.
Conjugation	FITC
Storage Condition	Store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD24 molecule
Database Link	Entrez Gene 100133941 Human UniProt ID P25063
Background	CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4; it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.
Synonyms	X62 heat stable antigen, HSA
Reference Data

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