ITGB1BP1 Human shRNA Plasmid Kit (Locus ID 9270)

Specifications

Product Data
Product Name	ITGB1BP1 Human shRNA Plasmid Kit (Locus ID 9270)
Locus ID	9270
UniProt ID	O14713
Synonyms	ICAP-1A; ICAP-1alpha; ICAP-1B; ICAP1; ICAP1A; ICAP1B
Vector	pRS
Format	Retroviral plasmids
Kit Components	ITGB1BP1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 9270). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
RefSeq	NM_001319066, NM_001319067, NM_001319068, NM_001319069, NM_001319070, NM_004763, NM_022334, NR_134951, NR_134952, NR_134953, NR_134954, NR_134955, NR_134956, NR_134957, NM_004763.1, NM_004763.2, NM_004763.3, NM_004763.4, NM_022334.1, NM_022334.2, NM_022334.3, NM_022334.4, BC012264, BC012264.1, BM823938, NM_001369744, NM_001369746, NM_001369747, NM_001369749, NM_001369745, NM_001369748, NM_001369750, NM_022334.5, NM_004763.5
Summary	The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed	OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.