SERPINB3 Human Recombinant Protein

Specifications

Product Data
Species	Human
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) M1-P390
Tag	C-Avi&6His
Buffer	Lyophilized from a 0.2 um filtered solution of 2umM Na2HPO4, 2umM NaH2PO4, pH7.4
Note	Recombinant Human Serpin B3 is produced by E.coli. The target gene encoding M1-P390 is expressed with a Avi&;6His tag at the C terminus.
Storage	Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability	12 months from date of despatch
Reference Data
Locus ID	6317
UniProt ID	P29508
Synonyms	Serpin B3; Protein T4-A; Squamous cell carcinoma antigen 1; SCCA-1;serine (or cysteine)proteinase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B(ovalbumin), member 3; Squamous cell carcinoma antigen 1; T4-A;SCCA1
Summary	Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpins are known to inhibit serine proteases and some can inhibit caspases and papain-like cysteine proteases. Serpin B3 is also a member of the subgroup ovalbumin-related serpins which takes part in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. Serpin B3 is also a tumor marker for squamous cell carcinomas in diverse areas including the cervix, head, neck and lung. Different from typical serpins, serpin B3 inhibits papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases
Protein Families	Druggable Genome, Secreted Protein

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