PAK2 (NM_002577) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) GPHMTDEEIM EKLRTIVSIG DPKKKYTRYE KIGQGASGTV FTATDVALGQ EVAIKQINLQ KQPKKELIIN EILVMKELKN PNIVNFLDSY LVGDELFVVM EYLAGGSLTD VVTETCMDEA QIAAVCRECL QALEFLHANQ VIHRDIKSDN VLLGMEGSVK LTDFGFCAQI TPEQSKRSTM VGTPYWMAPE VVTRKAYGPK VDIWSLGIMA IEMVEGEPPY LNENPLRALY LIATNGTPEL QNPEKLSPIF RDFLNRCLEM DVEKRGSAKE LLQHPFLKLA KPLSSLTPLI MAAKEAMKSN R
Tag	Tag Free
Predicted MW	33.5 kDa
Concentration	lot specific
Purity	>90% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Storage	Store at -80°C.
Stability	Stable at -80°C for 12 months from date of receipt. Protein should be thawed on ice. Protein can be flash-frozen in liquid nitrogen and stored at -80°C.
Bioactivity	Specific activity was determined as 85,806 pmoles/min/µg, according to the Zlyte assay protocol
Endotoxin	< 0.1 ng/µg of protein (< 1EU/µg)
Reference Data
RefSeq	NP_002568
Locus ID	5062
UniProt ID	Q13177
Refseq Size	6139
Cytogenetics	3q29
Refseq ORF	1572
Synonyms	PAK65; PAKgamma
Summary	The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Axon guidance, ErbB signaling pathway, Focal adhesion, MAPK signaling pathway, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway

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